Huntington Disease (HD)

▪️It is a progressive genetic disorder which affects the brain.
▪️It causes uncontrolled movements, impaired coordination of balance and movement, a decline in cognitive abilities, difficulty in concentrating and memory lapses, mood swings and personality changes.
▪️The HTT genes are involved in the production of a protein called huntingtin. They provide the instruction for making the protein.
▪️Mutated genes provide faulty instructions leading to production of abnormal huntingtin proteins and formation of clumps.
▪️These clumps disrupt the normal functioning of the brain cells, which eventually leads to death of neurons in the brain, resulting in Huntington disease.
▪️No cure exists, but drugs, physiotherapy and talk therapy can help manage some symptoms.